Effect of ethyl apovincaminate on cerebral, cardiac and renal flow rate in dogs in the course of administration
Szmolenszky, T.; Török, B.
Arzneimittel-Forschung 26(10a): 1914-1917
1976
ISSN/ISBN: 0004-4172 PMID: 1037214 Document Number: 96759
Cerebral, myocardial and renal capillary flow rate was significantly increased by 10 to 20 mug/kg/min doses of ethyl apovincaminate (RGH-4405, Cavinton) injected in slow infusion to dogs. These effects were long-lasting. Since perfusion pressure and heart rate were not affected by the compound, it was concluded that increased flow rate was attributable to decrease of peripheral vascular resistance. Results indicate that Cavinton has a vasodilatory effect.