Mechanism of the diuretic effect of eufillin
Kantariia, V.A.; Lebedev, A.A.
Farmakologiia i Toksikologiia 38(4): 430-433
1975
ISSN/ISBN: 0014-8318 PMID: 1213129 Document Number: 96014
In acute experiments on rats the xanthine diuretic euphylline did not block the short-circuited current in the proximal tubule, nor did it lower the transtubular potential and the transepithelial resistance of the nephron wall. The diuretic speeded up significantly the passage of the tubular fluid along the proximal region of the nephron and Henle's loop. The dihydroergotoxin and inderal blocking of adrenoreceptors did not produce any influence on the renal effects of the xanthine agent. Reserpine totally blocked the diuretic and saluretic effects of euphylline, whereas other sympatholytics, such as alpha-methyl-dofa, anthabus and hemedin, did not modify the action of the diuretic.