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Pancytopenia after a single intradermal infiltration of methotrexate

Cohen, P.R.; Schulze, K.E.; Nelson, B.R.

Journal of Drugs in Dermatology Jdd 4(5): 648-651

2005

ISSN/ISBN: 1545-9616
PMID: 16167425
Document Number: 9546
Methotrexate-related hematologic toxicity may include leukopenia, thrombocytopenia, megaloblastic anemia, and pancytopenia. We report a woman with hypertensive renal disease who was receiving hemodialysis and developed pancytopenia following a single intradermal infiltration of 25 mg of methotrexate. Caution should be exercised when considering the use of either systemic or intralesional methotrexate therapy in patients with risk factors that have been implicated in the development of adverse hematologic side effects: renal dysfunction, possible drug interactions, and advanced age.

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Pancytopenia after a single intradermal infiltration of methotrexate

Aspe de la Iglesia, B.; Sánchez Bursón, J.; Graña Gil, J.; Galdo Fernández, F. 1990: Pancytopenia and opportunistic infections in rheumatoid arthritis treated with methotrexate Revista Clinica Espanola 187(4): 208-209
Shiver, M.B.; Hall, L.A.; Conner, K.B.; Brown, G.E.; Cheung, W.L.; Wirges, M.L. 2014: Cutaneous erosions: a herald for impending pancytopenia in methotrexate toxicity Dermatology Online Journal 20(7)
Tanaka, Y.; Shiozawa, K.; Nishibayashi, Y.; Imura, S. 1992: Methotrexate induced early onset pancytopenia in rheumatoid arthritis: drug allergy? Idiosyncrasy? Journal of Rheumatology 19(8): 1320-1321
Leipzig, J.R.; Slavin, R.G. 1997: Single intradermal skin tests Ear Nose and Throat Journal 76(1): 16
Zrubek, H.; Szymański, C.Z.; Czajka, R.; Oleszczuk, J. 1984: Comparison of the course of healing of abdominal wall wound after skin suturing with ordinary single sutures and continuous intradermal suture Ginekologia Polska 55(11): 851-853
Alshimmiri, M.M.; Al-Saleh, E.A.; Al-Harmi, J.A.; AlSalili, M.B.; Adwani, A.A.; Ibrahim, M.E. 2003: Treatment of ectopic pregnancy with a single intramuscular dose of methotrexate Archives of Gynecology and Obstetrics 268(3): 181-183
Feo, C.Francesco.; Cossu, M.Laura.; Ginesu, G.Carlo.; Fancellu, A.; Scanu, A.Mario.; Piras, N.; Cherchi, G.; Cossu, A.; Sotgiu, G.; Pazzona, M.; Porcu, A. 2017: Perineural infiltration as a prognostic factor in surgically treated gallbladder cancer: a single center experience and literature review Annali Italiani di Chirurgia 6
Kamen, B.A.; Moulder, J.E.; Kun, L.E.; Ring, B.J.; Adams, S.M.; Fish, B.L.; Holcenberg, J.S. 1984: Effects of single-dose and fractionated cranial irradiation on rat brain accumulation of methotrexate Cancer Research 44(11): 5092-5094
Sites, C.K. 1995: Treatment of ectopic pregnancy with single-dose methotrexate in a patient with an intrauterine device. A case report Journal of Reproductive Medicine 40(11): 800-802
Rabischong, B.; Tran, X.; Sleiman, A.A.; Larraín, D.; Jaffeux, P.; Aublet-Cuvelier, B.; Pouly, J.-L.; Fernandez, H.é 2011: Predictive factors of failure in management of ectopic pregnancy with single-dose methotrexate: a general population-based analysis from the Auvergne Register, France Fertility and Sterility 95(1): 401
Osterwalder, J.J.; Knoblauch, A. 1991: Randomized and controlled single-case study--a scientific method for individual and difficult therapy decisions in clinical practice exemplified with methotrexate use in asthma Schweizerische Rundschau für Medizin Praxis 80(43): 1168-1172
Hassan, H.T.; Krog, C.; Stockschläder, M.; Schleimer, B.; Zeller, W.; Krüger, W.; Erttmann, R.; Zander, A.R. 1997: Factors influencing the haematological recovery after allogeneic bone marrow transplantation in leukaemia patients treated with methotrexate-containing GVHD prophylaxis: a single-centre experience Anticancer Research 17(1b): 589-599
Athanassiou, A.E.; Potamianou, A.; Bountouroglou, N.; Ziras, N.; Frangoulidis, A.; Varthalitis, J.; Karvounis, N.; Chrysanthou, C.; Pectasidis, D. 2002: Methotrexate, etoposide, ifosfamide and cisplatin (MVIP): an effective first-line therapy for IGCCC intermediate / poor prognosis patients with germ-cell tumors. Single institution experience Journal of BUON: Official Journal of the Balkan Union of Oncology 7(1): 35-41
Cadman, E.C.; Glick, J.H.; Cross, J.; Horton, J.; Taylor, S.G. 1984: Sequential methotrexate and 5-FU in CMFP (cyclophosphamide, methotrexate, 5-FU, and prednisone) therapy for breast cancer Cancer Treatment Reports 68(6): 877-879
Iqbal, M.P.; Malik, I.; Mehboobali, N. 1992: Appearance of a methotrexate binding plasma protein during high dose methotrexate therapy JPMA. Journal of the Pakistan Medical Association 42(8): 193-196
Kinahan, J.J.; Otten, M.; Grindey, G.B. 1979: Evaluation of ribonucleoside and deoxyribonucleoside triphosphate pools in cultured leukemia cells during exposure to methotrexate or methotrexate plus thymidine Cancer Research 39(9): 3531-3539
Schlegel, H.B.; Poe, M.; Hoogsteen, K. 1981: Models for the binding of methotrexate to Escherichia coli dihydrofolate reductase: direct effect of carboxylate of aspartic acid 27 upon ultraviolet spectrum of methotrexate Molecular Pharmacology 20(1): 154-158
van Dooren-Greebe, R.J.; Kuijpers, A.L.; Termorshuizen, F.; van de Kerkhof, P.C. 1995: Interruption of long-term methotrexate treatment in psoriasis. Evaluation of clinical course and laboratory parameters after discontinuation and reintroduction of weekly oral methotrexate Acta Dermato-Venereologica 75(5): 393-396
Pizzocaro, G.; Milani, A.; Piva, L.; Faustini, M.; Spino, E. 1991: Methotrexate, vinblastine, adriamycin and cisplatin versus methotrexate and cisplatin in advanced urothelial cancer. A randomized study European Urology 20(2): 89-92
Curry, S.L.; Blessing, J.A.; Disaia, P.J.; Soper, J.T.; Twiggs, L.B. 1989: A prospective randomized comparison of methotrexate, dactinomycin, and chlorambucil versus methotrexate, dactinomycin, cyclophosphamide, doxorubicin, melphalan, hydroxyurea, and vincristine in "poor prognosis" metastatic gestational trophoblastic disease: a Gynecologic Oncology Group study Obstetrics and Gynecology 73(3 Pt 1): 357-362