Predictive factors of failure in management of ectopic pregnancy with single-dose methotrexate: a general population-based analysis from the Auvergne Register, France

Rabischong, B.; Tran, X.; Sleiman, A.A.; Larraín, D.; Jaffeux, P.; Aublet-Cuvelier, B.; Pouly, J.-L.; Fernandez, H.é; Rabischong, B; Tran, X; Sleiman, A.A; Larraín, D; Jaffeux, P; Aublet-Cuvelier, B; Pouly, J.-L; Fernandez, H.?

doi:10.1016/j.fertnstert.2010.08.025

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Predictive factors of failure in management of ectopic pregnancy with single-dose methotrexate: a general population-based analysis from the Auvergne Register, France

Rabischong, B.; Tran, X.; Sleiman, A.A.; Larraín, D.; Jaffeux, P.; Aublet-Cuvelier, B.; Pouly, J.-L.; Fernandez, H.é

Fertility and Sterility 95(1): 401

2011

ISSN/ISBN: 1556-5653

PMID: 20850718

DOI: 10.1016/j.fertnstert.2010.08.025

Document Number: 218504

In a general population setting, the existence of a learning curve for treatment of ectopic pregnancy with single-dose methotrexate has been demonstrated, because a significant decrease in failure rate can be achieved over time. Despite this finding, the risk of single-dose methotrexate failure increases significantly in patients with initial hCG levels>1,300 IU/L and/or in women who report having ever used combined oral contraception before pregnancy.