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PVP-iodine: history, toxicity and therapeutic uses

Shelanski, H.A.; Shelanski, M.V.

Journal of the International College of Surgeons 25(6): 727-734

1956

ISSN/ISBN: 0096-557X
PMID: 13332267
Document Number: 9536
The chemical, physiologic and pharmaceutical aspects, as well as the uses, of polyvinylpyrrolidone (povidone) have been presented, together with the toxicologic and therapeutic evaluation of PVPiodine as compared with Lugol's solution and tincture of iodine. These studies show that the toxicity of PVP-iodine is much less than that of iodine in the tincture or in Lugol's solution. Clinical studies show that PVP-iodine is safe and effective in the treatment of a variety of infections of the skin and mucosa. It has been found effective in the treatment of thrush. With PVP-iodine the germicidal action of the iodine is prolonged and the danger of cutaneous irritation, sensitization, reactions and burns is minimized. Whereas tincture of iodine presents a hazard on accidental ingestion, PVP-iodine presents no such danger, because it is only from one-fourth to one-ninth as toxic. PVP-iodine presents iodine in a form of low toxicity but of high germicidal action. It has been found valuable in the treatment of a variety of skin and mucosal infections produced by many different types of bacteria.

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PVP-iodine: history, toxicity and therapeutic uses

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