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Post-hepatitic aplasia treated by grafts of allogenic bone marrow. Remission for more than 2 years. Persistance of a total hematopoietic chimera. Graft versus host reaction

Rochant, H.; Mannoni, P.; Brun, B.; Beaujean, F.; Kritvitzki, A.; Duval, J.; Dreyfus, B.

La Nouvelle Presse Medicale 4(16): 1183-1188

1975

ISSN/ISBN: 0301-1518
PMID: 240153
Document Number: 94844
A successfull bone marrow transplant was achieved in a case of post hepatitic aplastic anemia after cyclophosphamide immunosuppression. Caryotype analysis, erythrocytic phenotype and IgG Gm allotype demonstrated evidence of complete chimerism. Anti-thymocyte serum undoubtly was able to suppress a life threatening episode of graft versus host reaction. Severe long lasting skin lesions are now persisting 2 years after the graft.

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