Inhibitory effect of interferon on multiplication of Friend leukemia cells in vivo

Rossi, G.B.; Marchegiani, M.; Matarese, G.P.; Gresser, I.

Journal of the National Cancer Institute 54(4): 993-996

1975


ISSN/ISBN: 0027-8874
PMID: 1127730
Document Number: 94476
The multiplication of Friend leukemia cells in the spleens of irradiated or nonirradiated histocompatible DBA/2 mice was determined by the uptake of 125-5-iodo-2'-deoxyuridine. The multiplication was inhibited by daily treatment with mouse interferon preparations or the interferon inducer, Newcastle disease virus. Since, under the experimental conditions used, the proliferation of the Friend leukemia cells was independent of the replication of the Friend virus, the inhibitory effect of interferon might not be mediated by an antiviral effect but by some other mechanism.

Document emailed within 1 workday
Secure & encrypted payments