Effect of mitomycin C on the structure of human chromosomes observed in metaphase after labelling by moderate thermal denaturation
Ayraud, N.; Cantrelle, C.; Lloyd, M.
Comptes Rendus des Seances de la Societe de Biologie et de ses Filiales 169(6): 1573-1578
1975
ISSN/ISBN: 0037-9026 PMID: 132250 Document Number: 94168
Mitomycin C induced chromosome rearrangements were analysed in cultured human leukocytes by reverse banding technique. Breaks and chromosomal exchanges involved preferentialy the entromeric region of some chromosomes (1, 5, 9, 16, and 20). Associations between acrocentric chromosomes was not found to be increased. But acrocentric associations with centromeric regions were frequently present. The differences between the mechanism of exchanges and breaks are discussed. The part of heterochromatin in post replication DNA repair is considered.