Effect of thymocyte autotransplantation on postradiation regeneration of hematopoiesis
Fedotova, M.I.; Zimin, I.I.
Biulleten' Eksperimental'noi Biologii i Meditsiny 79(6): 32-34
1975
ISSN/ISBN: 0365-9615 PMID: 1083259 Document Number: 93616
Experiments were conducted on Wistar rats irradiated in a dose of 400 R; a study was made of the effect of thymocyte autotransplantation (4-10(8)--8-10(8)) on the restoration of cell number of the bone marrow and the spleen. There was revealed a significant stimulating effect of autotransplantation of thymocytes on the erythroid and granulocytic series in the bone marrow and on the lymphoid one in the spleen during the restoration (the 5 th-- 7 th days) after the irradiation. Irradiation of the thymocyte suspension with gamma-rays in a dose of 10 000 R failed to prevent the effect of autotransplantation on the bone marrow, but decreased its stimulating effect. A conclusion was drawn on the interaction of the administered thymocytes with the stem hemopoietic cell.