Trial prevention of the embryolethal properties of suramin in the mouse by adjuvant progesterone
Mercier-Parot, L.; Tuchmann-Duplessis, H.
Comptes Rendus des Seances de la Societe de Biologie et de ses Filiales 169(3): 503-506
1975
ISSN/ISBN: 0037-9026 PMID: 129191 Document Number: 93591
Suramine, a trypanocidal drug, has an embryo-lethal and teratogenic action in Rodents. Like Triton W.R. 1339 suramine modifies the lysosomes of the visceral yolk sac. In the mouse the attempts to correct the embryolethal action by a simultaneous progesterone treatment failed while the hormonal treatment is capable to suppress the embryolethality in Triton W.R. 1339 treated mice.
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