Hospital-acquired salicylate intoxication. report of a case with psychosis, acidosis, and coma
Good, A.E.; Welch, M.H.
Journal of Rheumatology 2(1): 52-60
1975
ISSN/ISBN: 0315-162X PMID: 1185735 Document Number: 93561
A case of salicylate intoxication from repeated therapeutic doses of aspirin is reported in an adult with impairment of salicylate elimination. Evolution of acid-base disturbance from respiratory alkalosis to metablic acidosis is documented. Serum salicylate levels during several years of therapy demonstrate the acquisition of impaired elimination of the drug. This case illustrates the practical importance of special features of salicylate accumulation kinetics emphasized in a recent review.