Type 4 renal tubular acidosis caused by spironolactone. A case report
Bruno, C.M.; Neri, S.; D'Angelo, G.; D'Amico, R.; Raciti, C.; Urso, G.
Minerva Medica 88(3): 93-95
1997
ISSN/ISBN: 0026-4806 PMID: 9148232 Document Number: 480933
The authors describe a case of type 4 renal tubular acidosis, observed in a subject with liver cirrhosis, the pathogenetic cause of which was probably the assumption of spironolactone. It is thought that, even if such an eventuality is not very frequent, it must be considered in clinical practice, in view of the negative consequences that the reduction in urinary ammonium excretion and hyponatriemia, together with this particular form of acidosis, may have on the neurological state of the patients.