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Local blistering reaction complicating subcutaneous injection of pegylated interferon in a patient with hepatitis C

Gallina, K.; Brodell, R.T.; Naffah, F.; Nedorost, S.

Journal of Drugs in Dermatology Jdd 2(1): 63-67

2003

ISSN/ISBN: 1545-9616
PMID: 12852384
Document Number: 9283
PEG-Intron is a covalent conjugate of recombinant alpha-2b interferon with monomethoxy polyethylene glycol (PEG). Compared to standard interferon-alpha injections, this preparation has a longer half-life allowing for once-weekly injections and superior antiviral efficacy in the treatment of hepatitis C when used in combination with ribavirin. We report the first case of a local blistering reaction developing in a patient receiving pegylated interferon-alpha-2b. Previous reports of local cutaneous reactions to standard and pegylated interferon-alpha are reviewed and the pathophysiological mechanisms are discussed.

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Local blistering reaction complicating subcutaneous injection of pegylated interferon in a patient with hepatitis C

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