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Corticoids and alveolar surfactant. Experimental study

Cardellino, G.; Dalmasso, F.; Garbagni, R.; Sappé, D.

Minerva Medica 66(53): 2657-2659

1975

ISSN/ISBN: 0026-4806
PMID: 1173939
Document Number: 92288
The effect of cortisone on the production of surfactant was studied by measuring the tensioactive property of the alveolar fluid, evaluated with Pattle's method. The stability ratio (R.S.) values obtained in 12 guinea-pigs following cortisone administration were all within normal limits. In rabbits treated with prednisolone during a number of fast days, S.R. values were lower than normal in 9 cases out of 10. The results of this study would seem to exclude any influence of the administration of cortisone on the activity of the alveolar surfactant.

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