Rapid production of a biotin deficiency in mice
Mayorbre, M.L.; Veuthey, F.; Rous, S.; Favarger, P.
Comptes Rendus des Seances de la Societe de Biologie et de ses Filiales 169(4): 892-898
1975
ISSN/ISBN: 0037-9026 PMID: 2375 Document Number: 91941
This work describes a rapid method for the production of a biotin-deficiency in mice. Besides classical morphological symptoms, a decrease of activities of some biotin-dependent enzymes was also observed. The biotin-enzymes are not inhibited at the same extent in a same organ and the metabolic changes do not always follow the enzymatic modifications.