Synthesis of nicotinamide adenine dinucleotide in the nuclei of pigeon erythrocytes
Nemchinskaia, V.L.; Makarova, T.G.; Mozhenok, T.P.; Braun, A.D.
Tsitologiia 17(8): 960-964
1975
ISSN/ISBN: 0041-3771 PMID: 181878 Document Number: 91775
The nuclei of pigeon erythrocytes are capable of synthesizing NAD from nicotinamid-mononucleotides and ATP. Some data on the kinetics of NAD-pyrophosphorylase have been obtained: the optimal concentration of nuclei and the effect of various incubation time. The pretreatment of nuclei by Triton X-100, or by ultrasonics enhances NAD synthesis. The results suggest that cyclic 3',5'-AMP (Fluka) may have no effect on NAD synthesis. The control of the cell metabolism by NAD formation is considered.
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