Effects of colchicine and of emetine on capillary permeability
Toscano Rico, J.; Gião T Rico, J.M.; Zambelli de Almeida, M.T.; Cravo, A.C.; Costa Ferreira, J.M.
Comptes Rendus des Seances de la Societe de Biologie et de ses Filiales 169(3): 749-751
1975
ISSN/ISBN: 0037-9026 PMID: 129229 Document Number: 91600
Colchicine and emetine administered locally in the hind paw of the rats increased markedly the capillar permeability. The action may be strongly inhibited by methysergide (0.2 mug). Mepyramine (0.5 mug) is not so active and indomethacine (1 mg/kg per os), even less. As some prostaglandines release serotonine and histamine (8) it is possible that some liberation of these mediators may be attribuable to a previous release of prostaglandines, but the experiments suggest also the possibility of a direct and concomitant release of those two mediators by the alkaloids assayed.