Tissue levels of prostaglandin e following heterotopic rat heart allografting
Jaffe, B.M.; Moore, T.C.; Vigran, T.S.
Surgery 78(4): 481-484
1975
ISSN/ISBN: 0039-6060 PMID: 1101430 Document Number: 90741
Heterotopic rat heart allografts were performed in 35 rats. At intervals after transplantation, rats were killed and tissue concentrations of immunoassayable prostaglandin E (PGE) were measured in the native heart, transplanted heart, spleen, and thymus. A significant increase in allograft PGE activity was observed at days 5 through 7, coinciding with the onset of the rejection reaction. These studies implicate PGE in the host response to allografting, but further studies are needed to determine what (if any) role prostaglandins play in the rejection reaction.