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Embryonic antigens shared between chemically induced lymphosarcomas and fibrosarcomas of the mouse

Ménard, S.; Colnaghi, M.I.

Journal of the National Cancer Institute 54(2): 479-481

1975

ISSN/ISBN: 0027-8874
PMID: 1172784
Document Number: 90608
An antiserum obtained by the immunization of C57BL/HeDp mice with a pool of C3HF/Dp 7,12-dimethylbenzɑanthracene (DMBA)-induced fibrosarcomas exerted a specific cytotoxic activity in vitro on C57BL/HeDp chemically induced lymphosarcomas. Conversely, C57BL/HeDp spleen cells sensitized against C3Hf/Dp chemically induced lymphosarcomas or embryo cells were cytotoxic for plated cells of syngeneic DMBA-induced fibrosarcomas. Absorption studies with antiembryo and antilymphoma antisera showed that embryonic antigens were shared between lymphosarcomas and fibrosarcomas and that all serologically defined antigens present on lymphoma cells, including virus-related antigens, were also on fibrosarcoma cells.

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