The mechanism of the acute action of insulin
Söling, H.D.
Münchener Medizinische Wochenschrift 117(41): 1635-1638
1975
ISSN/ISBN: 0341-3098 PMID: 127120 Document Number: 90371
All the known acute actions of insulin are based on the reaction of insulin with specific insulin receptors in the cell membranes of the insulin-sensitive organs. The reaction of insulin with these receptors leads, through changes in the membrane structure, to changes in the permeability of the cell membrane, the activity of the normal membrane K+/Na+ATPase and adenyl cyclase. From this results the multiplicity of acute insulin effects on numerous metabolic quantities, following a kind of intensifier system. Under physiological conditions, the effect of insulin on the liver metabolism plays the central role for the maintenance of blood sugar homeostasis.