Use of high-dosage trimethoprim-sulfamethoxazole in sinusitis
Whitehead, E.
Canadian Medical Association Journal 112(13 Spec No): 89-90
1975
ISSN/ISBN: 0008-4409 PMID: 1137832 Document Number: 89887
The combination trimethoprim-sulfamethoxazole was given in high dosage (four tablets twice daily) for either 2 or 5 days to 20 patients with sinusitis diagnosed on clinical grounds. In 11 the infection was improved or cured. Swabs cultured from 18 patients of the series produced no growth in 8. The organisms most likely to be isolated are Hemophilus influenzae and Diplococcus pneumoniae.