Significance of nerve transplantation in surgery of the peripheral nerves
Millesi, H.
Zentralblatt für Chirurgie 100(25): 1537-1546
1975
ISSN/ISBN: 0044-409X PMID: 773044 Document Number: 89089
NMRI mice of both sexes were, from the first to the tenth day of life, either stimulated by means of handling, or sensorically, or not stimulated at all (the control group). On the tenth day of life, they were separated from their mothers, inoculated intraperitoneally with E.coli O 111 and subsequently subjected to a total deprivation of food and water. The handling-group animals died significantly (1% level) faster than did the sensorically stimulated and the non-treated control group animals. No significant differences could be found in the mortality rates of the last two mentioned groups. After subdividing the animals into five weight classes, a comparative analysis of the three groups showed that the differences in mortality were independent of body weight. The significance of these first animal experiment data on the influence of early experience on the course of infectious diseases in childhood is discussed.