Hypercoagulability in the nephrotic syndrome of children
Vargas, R.; Pizzuto, J.; Bosque, J.D.; Santos, D.
Archivos de Investigacion Medica 6(1): 23-32
1975
ISSN/ISBN: 0066-6769 PMID: 1156076 Document Number: 88747
Several coagulation factors were studied in twenty children less than 16 years old, bearing nephrotic syndrome. Four of them were in remission. In nephrotic syndrome there is hypercoagulability. Coagulations factors such as fibrinogen, platelet factor III, prothrombin time, and factor V are markedly altered, and to a lesser degree, total number of platelets. Fibrin degradation products factors II, VII, X and VIII are also altered. During remission, all of them improve or become normal. In no case fibrin breakdown products were found in the blood. However, if found in urine, they would be considered as a pronostic index in nephropaties. Although etiologic factors remain unknown for most of the above-mentioned alterations, increased fibrinogen synthesis, decreased fibrinolytic plasms activity and renal damage have been demonstrated.