Endogenous vasoactive factors in children with nephrotic syndrome
Tsygin, A.N.; Kucherenko, A.G.; Markov, K.M.
Pediatriia 7: 30-33
1991
ISSN/ISBN: 0031-403X PMID: 1754319 Document Number: 375782
In accordance with the results of examining 40 children with nephrotic and mixed glomerulonephritis, it has been established that in the pathogenesis of the nephrotic syndrome of paramount importance is imbalance of the output of renal prostanoids, manifesting in the predominance of the vasopressor and proaggregate fraction--thromboxane A2 and in the deficiency of its antagonist prostacyclin that exerts a protective action on glomerular filtration. Sodium and water retention in patients with the nephrotic syndrome favours an increase of the content of antidiuretic hormone and plasma renin activity.