Enhancement of hypothalamic pressor responses in spontaneously hypertensive rats
Bunag, R.D.; Eferakeya, A.E.; Langdon, D.S.
American Journal of Physiology 228(1): 217-222
1975
ISSN/ISBN: 0002-9513 PMID: 1147012 Document Number: 88245
The cardiovascular effects of stimulating the posterior hypothalamus electrically were recorded in awake rats to permit in situ evaluation of central neural mechanisms without previous depression by anesthesia. Weak currents ineffective in normotensive or Doca-hypertensive rats elicited measurable pressor responses in spontaneously hypertensive rats, and when currents above threshold strength were used the responses were always larger in spontaneously hypertensive rats than in others. Reduction in reflex bradycardia probably contributed, at least in part, to the increased pressor responsiveness of spontaneously hypertensive rats to hypothalamic stimulation. Since pressor responses to injected norepinephrine or angiotensin were the same as or less than those in normotensive rats, it was concluded that some mechanism other than enhancement of cardiovascular reactivity is involved. Hypersensitivity of hypothalamic pressor areas was considered an attractive explanation but on the basis of the evidence available a possible hypersensitivity of other sites in the efferent neural pathway cannot be excluded.