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Comparison of lymphocyte stimulation and tuberculin skin reactivity in Mycobacterium bovis-infected Macaca mulatta

Muscoplat, C.C.; Thoen, C.O.; McLaughlin, R.M.; Thoenig, J.R.; Chen, A.W.; Johnson, D.W.

American Journal of Veterinary Research 36(5): 699-701

1975

ISSN/ISBN: 0002-9645
PMID: 806239
Document Number: 87906
Lymphocyte immunostimulation tests were conducted on M. bovis-infected and tuberculin-negative rhesus macaques (Macaca mulatta), using purified protein derivative (PPD) tuberculins prepared from strains of M. tuberculosis and M. avium. The stimulation of lymphocytes with M. tuberculosis PPD was significantly greater for the M. bovis-infected macaques than for the noninfected controls. The response of lymphocytes from M. bovis-infected macaques to stimulation with M. tuberculosis PPD was greater than the responses to stimulation with M. avium PPD. The results of in vitro lymphocyte stimulation and tuberculin skin re-activity were similar.

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