Experimental model of hepatitis A in rhesus monkeys (Macaca mulatta) infected with human hepatitis A virus
Shevtsova, Z.V.; Krylova, R.I.; Doroshenko, N.V.; Lomovskaia, I.B.; Belova, E.G.; Zairov, G.K.; Dzhelieva, Z.N.; Lapin, B.A.; Stakhanova, V.M.
Biulleten' Eksperimental'noi Biologii i Meditsiny 109(6): 536-539
1990
ISSN/ISBN: 0365-9615 PMID: 2168770 Document Number: 363278
The focus of this paper is characterization of Hepatitis A experimental model obtained for the first time in rhesus monkeys (M. mulatta) infected with fecal isolate from a patient with Hepatitis A (HAV-H1). Monkeys were susceptible to oral and intravenous reutes of HAV inoculation. The disease could be reproduced regularly in 4 passages as a result of which HAV strain continuously pathogenic for M. mulatta has been established. All 17 infected monkeys developed Hepatitis A with characteristic (except jaundice) patterns: shedding of virus with the stool, elevations of serum alanine aminotransferase level, appearance of IgM anti-HAV, morphological changes developed in the liver. Our data have demonstrated that the course of experimental Hepatitis A infection in M. mulatta is similar (in many respects) to that observed in man.