Case of implantation of human fetal thymus on the immunological reactivity in patients with Hodgkin's disease
Pekić, B.; Dujić, A.; Radojicić, B.; Radojicić, C.; Kolasinović, N.; Martinović, N.; Susaković, N.; Radovanović, L.
Bilten Za Hematologiju i Transfuziju 3(1-2): 105-119
1975
ISSN/ISBN: 0350-2023 PMID: 1225309 Document Number: 87233
Five patients with Hodgkin's disease (IV stage) were implanted with fetal human thymus. Implantation were performed under the fascia of rectus abdominis muscle. Thymuses were obtained from fetuses 4-5 month old in aseptic condition and stored in tissue culture medium 199, before implantation. Immunological studies carried out during 4-6 months, revealed the elevation of the number of the lymphocyte in the peripheral blood, normalization of the number of rosete forming cells (RFC) as well as the response of peripheral blood lymphocytes to phytohaemagglutinin (PHA) stimulation. Two patients had long improvement of immunological responsiveness, but the other 3 only a transitient one during the first month after implantation. The possibility of the immunologic treatment in the early stages of Hodgkin's disease is discussed.