Top Abstract Purchase Related
Home
>
Node
>
Subnode

Immunological cross-reactivity of anti-sera raised with fluoro dinitro benzene tagged normal human leukocytes against human leukaemic cells

Prema, S.; Madyastha, K.R.; Sahasrabudhe, M.B.

Indian Journal of Cancer 15(1): 53-57

1978

ISSN/ISBN: 0019-509X
PMID: 680783
Document Number: 135086
Fluorodinitro benzene (FDNB) tagged normal human leukocytes elicited immune response specific against human leukemic cells without any agglutinating activity against normal leukocytes. Tagged cells with 104 or 105 molecules of FDNB/cell exhibited maximum agglutinating activity against human leukemic cells. With higher or lower proportions of FDNB molecules/cell than this, the anti-leukemic immune response was reduced. Mechanism of action was discussed with special reference to the influence of FDNB-tagging on net cell surface charge, introduction of DNP-hapten moiety on cell surfaces and conformational changes on cell surfaces as a result FDNB induced transformations of hydrophylic groups into hydrophobic groups.

Document emailed within 1 workday
Secure & encrypted payments

Bias, W.B.; Santos, G.W.; Burke, P.J.; Mullins, G.M.; Humphrey, R.L. 1973: Normal human sera with cytotoxic reactivity to acute lymphocytic leukemia cells Transplantation Proceedings 5(1): 949-952
Fitchen, J.H.; Ferrone, S.; Lusis, A.J.; Cline, M.J. 1980: Cytotoxicity of anti-beta 2-microglobulin xenoantisera to human and murine myeloid progenitor cells and lack of cross-reactivity with colony-stimulating activity Journal of Immunology 124(6): 2906-2908
Miyoshi, I.; Kubonishi, I.; Yoshimoto, S.; Shiraishi, Y. 1981: A T-cell line derived from normal human cord leukocytes by co-culturing with human leukemic T-cells Gan 72(6): 978-981
Hassan, H.T.; Veit, A.; Maurer, H.R. 1991: Recombinant human GM-CSF significantly enhances the cytostatic activity of cell cycle specific anti-leukaemic drugs in HL-60 human myeloid leukaemia clonogenic cells in a capillary clonogenic micro-assay Anticancer Research 11(1): 481-485
Griffiss, J.M.; Goroff, D.K. 1981: Immunological cross-reaction between a naturally occurring galactan, agarose, and an LPS locus for immune lysis of Neisseria meningitidis by human sera Clinical and Experimental Immunology 43(1): 20-27
Johnstone, A.P.; Millard, R.E.; Hudson, L. 1982: The roles of leukaemic and residual normal cells in the proliferative response of chronic lymphocytic leukaemic lymphocytes to mitogens Clinical and Experimental Immunology 47(3): 689-696
Hassan, H.T.; Rees, J.K. 1990: Effect of AML serum on normal human myeloid differentiation and hexamethylene bisacetamide-induced granulocytic differentiation of the human HL-60 promyelocytic leukaemic cell line Folia Haematologica 117(1): 151-159
Linoli, O. 1974: Study on the aerobic and anaerobic flora, cells, leukocytes and minerals in the normal human unstimulated saliva Quaderni Sclavo di Diagnostica Clinica E di Laboratorio 10(2): 209-234
Maianskiĭ, A.N.; Molchanova, I.V.; Iskhakova, S.K.; Ado, E.I.; Vershinina, V.I. 1982: Immunological reactivity to the products of normal microflora. IV. Antibodies to common species-specific pneumococcal antigens in the human spectrum of antibacterial antibodies Zhurnal Mikrobiologii Epidemiologii i Immunobiologii 9: 86-89
MacKay, R.J.; Socher, S.H. 1992: Anti-equine tumor necrosis factor (TNF) activity of antisera raised against human TNF-alpha and peptide segments of human TNF-alpha American Journal of Veterinary Research 53(6): 921-924
Beketić-Oresković, L.; Sarcević, B.; Malenica, B.; Novak, D. 1993: Immunocytochemical reactivity of a mouse monoclonal antibody Cdi 315B raised against human breast carcinoma Neoplasma 40(2): 69-74
Klinman, D.M. 1992: Cross-reactivity of IgM-secreting B cells from normal BALB/c mice Journal of Immunology 149(11): 3569-3573
Melner, M.H.; Voigt, W.; Puett, D. 1986: Cross-reactivity of a monoclonal antibody directed against an estrogen-induced protein in MCF-7 human breast cancer cells with murine Leydig cell tumor proteins Cancer Research 46(1): 328-331
Birdsall, H.H.; Rossen, R.D. 1983: Characterization of anti-Fab' antibodies in human sera: identification of soluble immune complexes that contain hidden anti-KLH and blocking anti-immunoglobulins following immunization with keyhole limpet haemocyanin Clinical and Experimental Immunology 53(2): 497-504
Slesak, B.; Bogusławska-Jaworska, J.; Pejcz, J.; Harłozińska, A. 1989: Binding of lectins to human leukaemic cells Folia Haematologica 116(2): 251-259
Rainer, H.; Höcker, P.; Pittermann, E.; Moser, K. 1974: Reverse transcriptase of human leukaemic cells Wiener Klinische Wochenschrift 86(5): 117-122
Park, H.S. 1973: Immunologic reactivity between human trophoblast and cancer sera: a preliminary report Annals of Allergy 32(1): 29-34
Young, W.W.; Hakomori, S.I.; Levine, P. 1979: Characterization of anti-Forssman (anti-Fs) antibodies in human sera: their specificity and possible changes in patients with cancer Journal of Immunology 123(1): 92-96
Holm, G.; Björkholm, M.; Böttiger, B.; Mellstedt, H.; Pettersson, D.; Simonsson-Lindemalm, C. 1980: Antibody-dependent haemolytic activity of human leukaemic cells Clinical and Experimental Immunology 42(1): 121-126
Krajewski, A.S.; Dewar, A.E.; Seidelin, P.H.; Murray, R. 1983: Colony formation and interleukin 2 production by leukaemic human T cells Clinical and Experimental Immunology 54(1): 103-109