Reactivity and immunogenicity of the Sonne dysentery detergent monovaccine
Kambarova, O.I.; Sel'kina, L.E.; Shpiliuk, G.F.; Bodazhkova, K.N.; Dudkina, M.I.
Zhurnal Mikrobiologii Epidemiologii i Immunobiologii 12: 34-38
1975
ISSN/ISBN: 0372-9311 PMID: 766518 Document Number: 86910
The authors elaborated a method of isolation under industrial conditions of Shigella sonnei surface antigens by the treatment of the culture with a detergent (sodium laurylsulfate). The antigens obtained possessed a much lesser toxicity in comparison with the tryptic ones. A method of preparation of a detergent Sonne monovaccine with an increased antigen content (1.3 mg/ml) was described. Experimental series of the preparation were tested on 38 volunteers. A lower reactogenicity of the detergent vaccine (in comparison with the tryptic) and its marked immunological efficacy was demonstrated.