Phalloidin antagonists. 2. Protective effect of disilybine in phalloidin poisoning of isolated hepatocytes
Petzinger, V.E.; Homann, J.; Frimmer, M.
Arzneimittel-Forschung 25(4): 571-576
1975
ISSN/ISBN: 0004-4172 PMID: 1098677 Document Number: 85972
Phalloidin produces marked protrusions on the surface of isolated hepatocytes prepared from rat livers. This typical in-vitro effect of the mushroom toxin is prevented or inhibited by preincubation with disilybin. The antagonistic effect depends on the concentration of disilybin and might be caused by an inhibition of phalloidin binding.
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