Mydriatic effects using low concentrations of phenylephrine hydrochloride
Kubo, D.J.; Wing, T.W.; Polse, K.A.; Jauregui, M.J.
Journal of the American Optometric Association 46(8): 817-822
1975
ISSN/ISBN: 0003-0244 PMID: 1078357 Document Number: 85860
The dose response relationship of different concentrations of phenylephrine with and without prior application of topical anesthetic was measured to determine the minimum concentration which produced maximum mydriasis. As little as 0.125% phenylephrine caused mydriasis in some subjects and maximum mydriasis was achieved with 2%. Concentrations greater than 2% produced very little additional mydriasis. A therapeutically effective dose could be as low as 1% with prior installation of a topical anesthetic.