The effect of neutotropic substances on motor excitation in dogs induced by amizil
Zaostrovskiĭ, O.V.; Mil'shteĭn, G.I.
Biulleten' Eksperimental'noi Biologii i Meditsiny 79(5): 59-61
1975
ISSN/ISBN: 0365-9615 PMID: 1227596 Document Number: 85616
The motor activity of dogs was quantitatively recorded before and after the intramuscular injection of amizyl (2 mg/kg). Amizyl was found to induce hyperactivity for 2-3 hours. Galanthamine (3 mg/kg) blocked the effect of amizyl. Etaperazine was the most active substance of the neuroleptic tranquillizers tested. Chlorpromazine and diazepam deranged the dogs' state. Diazepam and haloperidol potentiated the effect of amizyl. Motor hyperactivity induced by amizyl is supposed to be connected with anticholinergic mechanisms; no neuroleptics with cholinolytic properties should be used for the treatment of amizyl intoxication.