Effects of anesthesia with inhalation anesthetics on excitation, conduction and refractory parameters of the heart. Experiments in dogs
Hahn, N.; Hörnchen, U.; Eichelkraut, W.
Arzneimittel-Forschung 46(3): 251-256
1996
ISSN/ISBN: 0004-4172 PMID: 8901144 Document Number: 462864
Cardiac excitation, conduction, and refractory parameters of the heart were investigated in 40 beagle dogs to obtain basic values under the influence of the following 9 inhalation anaesthetic regimes using HIS-bundle electrography and programmed stimulation: 1. halothane; 2. enflurane; 3. isoflurane; 4. halothane+nitrous oxide; 4. enflurane+nitrous oxide; 6. isoflurane+nitrous oxide; 7. alfentanil/midazolam/succinylcholine+nitrous oxide; 8. fentanyl/midazolam/pancuronium bromide+nitrous oxide; 9. propofol+nitrous oxide. It could be shown that inhalation anaesthetics under laboratory conditions exert some influences on the observed cardiac parameters, although they are not as strong as those of intravenous anaesthetics. Therefore their effects should be considered in experiments with other substances or in cardiovascular results.