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Effects of intravenous anaesthetics on excitation, conduction, and refractory parameters of the heart. Experimental study in the dog

Hahn, N.; Hörnchen, U.; Eichelkraut, W.

Arzneimittel-Forschung 45(4): 462-471

1995

ISSN/ISBN: 0004-4172
PMID: 7779143
Document Number: 440978
Cardiac excitation, conduction, and refractory parameters of the heart were investigated in 59 beagle dogs to obtain basic values under the influence of the following 11 intravenous anaesthetic regimes using HIS-bundle electrography and programmed stimulation: 1. Alfentanil/midazolam/succinylcholine; 2. alfentanil/midazolam/succinylcholine/atropine; 3. fentanyl/midazolam/pancuronium bromide; 4. fentanyl-droperidol/chloralose/urethane; 5. ketamine/xylazine; 6. ketamine/xylazine/atropine; 7. propionylpromazine/pentobarbital; 8. propionylpromazine/levomethadon; 9. propofol; 10. propofol/alfentanil; 11. Tiletamine-zolazepam. It could be shown, that some intravenous anaesthetics under laboratory conditions have a strong influence on the observed cardiac parameters that must be considered in experiments with other substances or in cardiovascular results.

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