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The enhanced cytotoxicity of combinations of 1-beta-D-arabinofuranosylcytosine and methotrexate

Edelstein, M.; Vietti, T.; Valeriote, F.

Cancer Research 35(6): 1555-1558

1975

ISSN/ISBN: 0008-5472
PMID: 1131822
Document Number: 85535
Although both 1-beta-D-arabinofuranosylcytosine (ara-C) and methotrexate are presumed to be toxic as a result of their interference with DNA synthesis, results obtained with L1210 cells in vivo suggest that the combination of ara-C and methotrexate is capable of killing cells by a mechanism not related simply to DNA synthesis inhibition. Simultaneous administration of ara-C and methotrexate, or administration of these two agents within a 10-hr interval, independent of order, produces a synergistic cell kill of L1210 cells but a less than additive effect on normal hematopoietic stem cells. The extent of synergy seems dependent upon the dose of ara-C.

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