Central nervous system pharmacology of propranolol
Iyer, K.S.; Govindankutty, A.; Radha, M.
Indian Journal of Physiology and Pharmacology 19(3): 152-156
1975
ISSN/ISBN: 0019-5499 PMID: 1205559 Document Number: 85415
In rats, propranolol potentiated alcohol and pentobarbitone hypnosis, but not barbital sleeping time, indicating enzyme inhibition as a possible mechanism of potentiation. Propranolol showed anticonvulsant effect on normal and reserpine treated rats by MES test, but showed dose related lowering of MET. Probable mechanisms are discussed.
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