Anti-Proliferation and Apoptosis Induction in Breast Cancer Cells by Cratoxylum cochinchinense Extract

Innajak, S.; Nilwarangoon, S.; Mahabusarakam, W.; Watanapokasin, R.

Journal of the Medical Association of Thailand 99 Suppl. 8: S84-S89


ISSN/ISBN: 0125-2208
PMID: 29901920
Document Number: 8535
Breast cancer is the most common invasive cancer in females worldwide. It was found about 37.5% in Thai To investigate the effect of Cratoxylum cochinchinense extract on anti-proliferation and apoptosis induction in breast cancer cells. Cell proliferation and cell viability assay were determined by MTT assay. Hoechst 33342 and JC-1 staining were used to determined nuclear morphological changes and mitochondrial membrane potential, respectively. C. cochinchinense extract showed anti-proliferation in MDA-MB-468 treated cells in a time- and dose-dependent manner with IC50 value of 19.19+0.8 μg/ml. In addition, C. cochinchinense extract induced nuclear condensation and apoptotic bodies in MDA-MB-468 treated cells. JC-1 staining revealed that C. cochinchinense extract induced mitochondrial membrane dysfunction. C. cochinchinense extract showed anti-proliferation and apoptosis induction properties in MDA-MB-468

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