Clofazimine as elective treatment for granulomatous cheilitis
Fdez-Freire, L.R.íg.; Serrano Gotarredona, A.; Bernabeu Wittel, J.; Pulpillo Ruiz, A.; Cabrera, R.ío.; Navarrete Ortega, M.; Conejo-Mir, J.án.
Journal of Drugs in Dermatology Jdd 4(3): 374-377
2005
ISSN/ISBN: 1545-9616 PMID: 15898297 Document Number: 8520
Cheilitis granulomatosa (CG) is a rare, idiopathic inflammatory disorder that usually affects young adults and clinically is characterized by diffuse, non-tender, soft to firm swelling of one or both lips. A variant of granulomatous cheilitis is Melkersson-Rosenthal syndrome when associated with facial paralysis and furrowed tongue. Several treatments have been used with variable success. We report 3 cases of GC treated with oral clofazimine 100 to 200 mg daily for 3 to 6 months obtaining regression of lesions in all treated cases. Hyperpigmentation and elevation of liver enzymes were observed as side effects.
Document emailed within 1 workday
