Evaluation of effectiveness of clofazimine therapy. I. Monitoring of absorption of clofazimine from gastrointestinal tract
Mathur, A.; Venkatesan, K.; Bharadwaj, V.P.; Ramu, G.
Indian Journal of Leprosy 57(1): 146-148
1985
ISSN/ISBN: 0254-9395 PMID: 3839813 Document Number: 242834
The quantity of clofazimine absorbed from the gastrointestinal tract when administered to lepromatous leprosy patients at varying single doses of 600 mg., 400 mg., 300 mg., and 100 mg. has been worked out by determining the amount of clofazimine present in total faecal excreta. Except in 100 mg. dose where the percentage absorption was 62.5 +/- 17 in all other case the values were around 45%. The efficacy of daily administration of 100 mg. clofazimine is discussed in this first article.