Induction of rho- mutants in Saccharomyces cerevisiae by guanidine hydrochloride. II. Conditions that prevent rho- induction
Juliani, M.H.; Da Costa, S.O.
Mutation Research 30(3): 335-342
1975
ISSN/ISBN: 0027-5107 PMID: 1105166 Document Number: 84859
The induction of rho- "petite" mutants by guanidine hydrochloride (GuHCl) is inhibited in several conditions. Anaerobiosis inhibited the induction either with or without cell multiplication. Both nalidixic acid (NA) and cycloheximide (CH) inhibited the induction of mutants. On the other hand, chloramphenicol (CAP) produced a dual effect: at low concentration it stimulated, at high concentration it inhibited, the induction. The effect of these different inhibitors on the transformation of rho+ mother cells into rho- by GuHCl is discussed.