Chemotherapeutic Agents in the Management of Gastric Cancer
Koven, B.J.
Journal of the Medical Society of New Jersey 61: 527-529
1964
ISSN/ISBN: 0025-7524 PMID: 14232374 Document Number: 8457
Carcinoma of the stomach is largely refractory to treatment with chemotherapy utilizing alkylating agents, such as nitrogen mustard and its newer analogs. However, some objective benefit may be produced with the drug 5-fluorouracil in about 20 per cent of selected cases. Since toxicity may be severe, the physician must be familiar with the clinical and laboratory abnormalities which this agent may produce in order to avoid irreversible toxic effects. Further modification of dosage schedules may improve the therapeutic index for this agent.
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