Bullous reaction to topical methchlorethamine in mycosis fungoides
Freed, J.; Wells, M.; Stetson, C.; Dongwoo, L.
Journal of Drugs in Dermatology Jdd 5(1): 66-67
2006
ISSN/ISBN: 1545-9616 PMID: 16468295 Document Number: 8400
We describe a patient with mycosis fungoides who developed a bulla shortly after the start of topical methchlorethamine. Dermal-epidermal separation has been reported to occur with topical methchlorethamine on histological examination. It is plausible that the compromised dermal-epidermal junction may manifest as a clinical bulla after a secondary insult. To our knowledge, clinical bulla formation due to topical methchlorethamine has not been reported.
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