Dynamics of inhibition of the hypophyso-adrenal function in the administration of isotonic solutions of hydrocortisone into various hypothalamic nuclei
Komissarenko, V.P.; Nesen, K.I.
Problemy Endokrinologii 21(4): 43-46
1975
ISSN/ISBN: 0375-9660 PMID: 1226363 Document Number: 83749
Injection of 1% hydrocortisone solution into the arcuate, ventromedial or supraoptic nucleus of the hypothalamus inhibited the activity of the hypophysis-adrenal system. This inhibition began 0.5 hours after the administration of the hormone into the microcellular nuclei and reached the maximum in 2 hours when the corticosteroid secretion was cut by about half. After the injection of hydrocortisone into the supraoptic nucleus inhibition of the hypophysis-adrenal system began later than in its administration into the arcuate or the ventromedial nucleus. In this case the level of corticosteroids began to decrease two hours after the injection, and in 3 hours it was half of the initial one. Apparently hydrocortisone retarded the synthesis of the corticotropine-releasing factor in the hypothalamic nuclei.