Interrelationship of the cardiovascular and digestive systems in the genesis of experimental atherosclerosis
Klimenko, E.D.; Martsevich, M.S.; Mukhina, A.P.; Shenkman, N.S.
Biulleten' Eksperimental'noi Biologii i Meditsiny 80(10): 29-33
1975
ISSN/ISBN: 0365-9615 PMID: 1227614 Document Number: 83717
In chronic experiments (up to 2 years) on dogs on atherogenic diets the motor activity of the gastrointestinal tract, cholesterol, the phospholipid level in the blood and in the intestinal secretion as well as the morphology of the small intestine and the vascular system were examined. At the early stages of atherosclerosis (up to 4 months) the rise of the blood cholesterol level was followed by an increase in the periods of the activity of the gastrointestinal tract, a rise of cholesterol discharge by the small intestine, and the development of the hypertrophic process in the mucous membrane. At the later stages a change in the mucous membrane of the small intestine was observed with development of a dystrophic-atrophic process, a disturbance of motor activity of the gastrointestinal tract and of the correlations between the cholesterol content in the blood and its discharge by the small intestine. This period was characterized by a high and persistent hypercholesterolemia and pronounced atherosclerotic changes in the vascular system.