Alpha-oxybenzylphosphinic acid, and its sodium salt (Phos) , which may be considered the prototype of a new group of drugs, the assimilotoria
Blum, F.; Schmid, R.
Helvetica Physiologica et Pharmacologica Acta 8(3): 272-285
1950
ISSN/ISBN: 0367-6242 PMID: 14793872 Document Number: 8232
1. The denomination "Assimilatoria" covers a new group of synthetic drugs, which are practically innoxious, no matter how they are applied. These drugs have the property of stimulating the assimilatory functions of the body; they thus help to prevent certain deficiencies of the organism. 2. The sodium salt of a-oxybenzylphosphinic acid (Phos) may be regarded as the prototype of an "Assimilatorium". It is perfectly harmless. In the surviving diaphragm of the rat suspended in a sugar containing Ringer's solution traversed by a current of 02, it stimulates the formation of glycogen. This effect corresponds to that of an addition of insulin. 3. Blum has formerly shown that, in animal experiments, with Pervitin, Phos counteracts the glycogen and sugar decrease. Phos acts in a similar way by lowering the consumption of glycogen in the presence of adrenalin by the rat diaphragm.
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