A New Concept for Detection of Bence Jones Proteinuria in Patients with Monoclonal Gammopathy

Hofmann, W.; Garbrecht, M.; Bradwell, A.R.; Guder, W.G.

Clinical Laboratory 50(3-4): 181-185

2004


ISSN/ISBN: 1433-6510
PMID: 15074473
Document Number: 8140
Bence Jones (free light chain - FLC) proteinuria is usually detected by immunofixation electrophoresis (IFE) of urine. With a new, automated immunoassay, it is now possible to quantify FLC in serum and urine. In the present study, we compared different routine methods for monoclonal FLC screening. From our results we conclude that the measurement of FLC in serum is highly sensitive and should replace urine tests. Additionally, possible kidney dysfunction, caused by nephrotoxicity of FLC, should be assessed by urine protein analysis and cystatin C measurements.

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A New Concept for Detection of Bence Jones Proteinuria in Patients with Monoclonal Gammopathy