The influence of amiodarone on results of the signal-averaged electrocardiogram
Kubik, L.; Michałkiewicz, D.
Polskie Archiwum Medycyny Wewnetrznej 95(4): 299-306
1996
PMID: 8755835 Document Number: 7822
The aim of this study was to assess if amiodarone hydrochloride administered intravenously influenced signal-averaged electrocardiogram and if this effect can be used in diagnosing patients prone to sustained ventricular tachycardia (sVT). Two hundred thirty seven patients were divided into 3 groups: group K--58 patients with no apparent heart disease, group W--121 patients with remote myocardial infarction and group C-58 patients with remote myocardial infarction and at least one episode of sVT. Signal-averaged electrocardiograms (SAECG) were assessed in time domain (QRS, LPD, RMS40) and frequency domain analysis logarhythmically (40 D, 60 A) and linearly [formula: see text] for windows lasting 120 and 140 ms, and starting 20, 40, 80 ms before the end and 60 ms after the beginning of QRS complex. Amiodarone hydrochloride increased frequency of late potentials (LP) in all groups especially in group C (K 5.2%-9.1%, W 33.9%-41.4%, C 75.9% -90.9%. Amiodarone hydrochloride prolonged total activation time--QRS (K -4.27 ms, W -6.06 ms, C -5.82 ms), time of low amplitude signals LPD (K -2.64 ms, W -2.87 ms, C -5.39 ms) and decreased the amplitude of RMS40 (K -2.12 mV, W -4.67 mV, C -5.0 mV). In group C the influence of amiodarone hydrochloride was found the strongest in the terminal part of the QRS complex whereas its influence on total activation time of QRS complex was weaker. We concluded that in patients prone to sVT amiodarone hydrochloride most strongly influenced the terminal part of QRS complex which suggested predominant influence on the zone of delayed conduction and amiodarone hydrochloride non significantly influenced on the results of frequency domain analysis.
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