Influence of antianginal drugs on Lypressin induced T-wave enhancement in the electrocardiogram of the rat
Leitold, M.; Hader, S.
Arzneimittel-Forschung 36(10): 1454-1457
1986
ISSN/ISBN: 0004-4172 PMID: 2949754 Document Number: 268302
Lypressin enhances the T-wave in the ECG of the anesthetized Sprague-Dawley rat and this has been used in screening for antianginal activity. After oral administration the durations of action of the organic nitrates, glyceryl trinitrate, isosorbide dinitrate, glyceryl 1,2-dinitrate, glyceryl 1,3-dinitrate and of SIN-1 (3-morpholinosydnonimine), molsidomine and nicorandil were shorter than those of verapamil and nifedipine. The sequence of the durations of action of the substances examined was the same in the rat as in man.