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Plasma iron clearance after single-dose iron-dextran (Imferon) infusion in iron deficiency anaemia

Kumar, R.; Gulati, R.C.; Gupta, S.P.

Indian Journal of Medical Research 62(7): 1039-1045

1974

ISSN/ISBN: 0019-5340
PMID: 4435914
Document Number: 75473
Ten iron-deficient patients each given a single total-dose infusion of an iron-dextran preparation. The pattern of serum Fe clearance was a double exponential with a fast component half-life of 6.6 h and a slow component half-life of 4.5 days. The pattern of haemoglobin rise was a single exponential. It is concluded that the injected Fe is cleared into more than one pool, that there is a simultaneous feed-back from pools to plasma and that Fe is steadily available for constant rate of haemoglobin synthesis.

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